Outbreak of aseptic meningitis and mumps after mass
vaccination with MMR vaccine using the Leningrad-Zagreb mumps strain.
da Cunha SS, Rodrigues LC, Barreto ML, Dourado I.
Data from routine surveillance during two mass
immunisation campaigns (MIC) with Measles-mumps-rubella (MMR)vaccine using
Leningrad-Zagreb mumps strain in two states in Brazil were analysed to estimate
the risk of vaccine-related meningitis and mumps. Increase in the incidence of
the two diseases was observed in both states, 3 weeks after the vaccination campaigns.
The estimated number of doses applied per one case of vaccine-related
meningitis ranged from 6199 (95% CI: 4854-8058) to 19,247 (95% CI:
12,648-29,513) depending on the diagnostic criteria used and state. It was 300 doses (95% CI: 286-317) for each
case of mumps. The implications for vaccination policy are discussed.
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